First Report of Lysozyme Amyloidosis with p.F21L/T88N Amino Acid Substitutions in a Russian Family

Amino Acid Sequence in Lysozyme

The previous paper in this series (Thompson, 1955) reported some amino acid sequences in lysozyme which were deduced from the structures of a number of small peptides isolated from partial acid hydrolysates by displacement chromatography on ion-exchange resins and further fractionation on paper chromatograms. Despite the success achieved by Partridge and co-workers (see Partridge & Brimley, 195...

Lysozyme amyloidosis – a case report and review of the literature

Lysozyme amyloidosis is an exceedingly rare hereditary autosomal dominant amyloidosis, which is characterized by the precipitation of lysozyme protein within the body, leading to multi-organ dysfunction. Herein, we present the case of a U.S. family affected by lysozyme amyloidosis. In particular, we report pericardial disease involvement leading to recurrent pericardial effusion, which to our k...

Scoring Amino Acid Substitutions In Φhage Genomes

Substitution matrices are among the most widely used scoring techniques : BLAST, Muscle and other alignment packages, all use them. However these matrices are general; they ignore organism specific properties and do not provide customized scoring schemes. We present a Φhage-specific scoring matrix based on the abundances of aligned substitutions. These matrices use information from approximatel...

Amino Acid Properties and Consequences of Substitutions

in silico analysis of amino acid substitutions in dna gyrase subunit a

the broad consumption of antibiotics such as fluoroquinolones and the genetic adaption of opportunistic pathogenic bacteria including pseudomonas aeruginosa , has led to develop of floroquinolone-resistant strains of pseudomonas aeruginosa . thus, the aim of the present study is to reveal the types of hot spot mutations occurring in selected dna gyrase subunit a gene in fluoroquinolone-resistan...